Nausea and vomiting Nausea and vomiting are common in patients with advanced cancer. Drugs with antimuscarinic effects antagonise prokinetic drugs and, if possible, should not be used concurrently. Bowel colic and excessive respiratory secretions may be reduced by a subcutaneous injection of hyoscine hydrobromide , hyoscine butylbromide , or glycopyrronium bromide. The majority of the drug is excreted via the kidney as glucuronides and to a much lesser extent as morphine. NO2AA09 Diamorphine is a narcotic analgesic which acts primarily on the central nervous system and smooth muscle. The use of physiological saline sodium chloride 0.

Uploader: Vonos
Date Added: 4 October 2006
File Size: 23.10 Mb
Operating Systems: Windows NT/2000/XP/2003/2003/7/8/10 MacOS 10/X
Downloads: 40521
Price: Free* [*Free Regsitration Required]

Ideally, the cause should be determined before treatment with an antiemetic is started. Read more about the different types of painkillers.

Diamorphine has been used in the treatment of terminally ill children. In the case of obstructive jaundice, further measures include administration of colestyramine. These control pain by blocking pain messages to the brain.

Diamorphine Hydrochloride BP 100 mg Lyophilisate for Solution for Injection

Marketing authorisation number s 9. Drugs from the different classes are used alone or in combination according to the type of pain and response to treatment. Pain management in palliative care is focused on achieving control of pain by administering the right drug in the right dose at the right time. The most common side effects are sedation, diamorpnine and vomiting, constipation and sweating.


Prescribing in palliative care | Medicines guidance | BNF content published by NICE

Great caution should be exercised in patients with a known tendency or history of drug abuse. It can also reduce breathlessness caused by a build up of fluid around the lung a pleural effusion.

When prescribing this medicine, patients should be told:.

Transdermal route Transdermal preparations of fentanyl and buprenorphine are available, they are not suitable for acute pain or in patients whose analgesic requirements are changing rapidly because the long time to steady state prevents rapid titration of the dose.

Formulations of transdermal patches are available as hourly, hourly and 7-day patches, for further information see buprenorphine.

To view the changes to a medicine you must sign up and log in. Oral medication is usually satisfactory unless there is severe nausea and vomiting, dysphagia, weakness, or coma, when parenteral medication may be necessary. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: Alcohol may enhance the sedative and hypotensive effects of diamorphine.

Parenteral route The equivalent parenteral dose of morphine subcutaneous, intramuscular, or intravenous is about half of the oral dose. Diazepam may be helpful for dyspnoea associated with anxiety.

A white to off-white, sterile, freeze dried powder of Diamorphine Hydrochloride BP for reconstitution for injection. Patients with cerebral tumours or uraemia may be susceptible to convulsions. Many patients wish to remain at home with their families. Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important. Careful assessment of symptoms and needs of the patient should be undertaken by a multidisciplinary team.


Midazolam Subcutaneous infusion solution should be monitored regularly both to check for precipitation and discolouration and to ensure that the infusion is running at the correct rate. Levomepromazine is used as an antiemetic; it is given by mouth or by subcutaneous injection at bedtime. Headache due to raised intracranial pressure often responds to a high dose of a corticosteroid, such as dexamethasone and should be given before 6 p.

Chronic painmg regularly every four hours by subcutaneous or intramuscular injection. To minimise the risk of infection no individual subcutaneous infusion solution should be used for longer than 24 hours. Cancer drugs can interact with some other medicines and herbal products.

In man, diamorphine has a half life of two to three minutes. Diamorphine hydrochloride is sometimes preferred, because being more soluble, it can be given in a smaller volume. Repeated administration of diamorphine may lead to dependence and tolerance developing. Back to top Accord-UK Ltd contact details.